National Championship Game:
Second-round games:
The Nittany Lions are ranked fourth, with the Fighting Irish at five.
Notre Dame had a strong regular season record of 13-1.
The illness comes as they prepare to face Penn State in the Orange Bowl on Thursday night.
Notre Dame plays the CFP after a stunning win in the quarterfinals.
That has led to speculation he could be on for a high pick in the 2025 NFL Draft.
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The showdown took place at the Superdome in New Orleans, Louisiana.
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The Orange Bowl against Penn State will take place at the Hard Rock Stadium.
It is not known who has been affected ahead of the College Football Playoff semifinal.
That came in a 23-10 victory over the No. 2 Georgia Bulldogs last week.
Semifinals:
Penn State won their quarterfinal 31-14 against Boise State on 31 December.